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1

Diffusional models useful in biopharmaceutics. Drug release rate processes

William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

1967

Language:

english

File:

PDF, 883 KB

english, 1967

2

In vitro and in vivo comparisons of constant resistance AC iontophoresis and DC iontophoresis

S.Kevin Li, William I. Higuchi, Honggang Zhu, Steven E. Kern, David J. Miller, Matthew S. Hastings

Journal:

Journal of Controlled Release

Year:

2003

Language:

english

File:

PDF, 320 KB

english, 2003

3

Effects of oxygen-containing terpenes as skin permeation enhancers on the lipoidal pathways of human epidermal membrane

Doungdaw Chantasart, Thaned Pongjanyakul, William I. Higuchi, S. Kevin Li

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 294 KB

english, 2009

4

Investigation of factors influencing release of solid drug dispersed in inert matrices IV. Some studies involving the polyvinyl chloride matrix

Saurabh J. Desai, Parvinder Singh, Anthony P. Simonelli, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

1966

Language:

english

File:

PDF, 410 KB

english, 1966

5

Investigation of factors influencing release of solid drug dispersed in inert matrices III. Quantitative studies involving the polyethylene plastic matrix

Saurabh J. Desai, Parvinder Singh, Anthony P. Simonelli, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

1966

Language:

english

File:

PDF, 420 KB

english, 1966

6

Investigation of factors influencing release of solid drug dispersed in inert matrices ii quantitation of procedures

Saurabh J. Desai, Parvinder Singh, Anthony P. Simonelli, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

1966

Language:

english

File:

PDF, 486 KB

english, 1966

7

Diffusional model for transport rate studies across membranes

Randall G. Stehle, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

1967

Language:

english

File:

PDF, 176 KB

english, 1967

8

Release rates of solid drug mixtures dispersed in inert matrices I. Noninteracting drug mixtures

Parvinder Singh, Saurabh J. Desai, Anthony P. Simonelli, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

1967

Language:

english

File:

PDF, 519 KB

english, 1967

9

Release rates of solid drug mixtures dispersed in inert matrices II. Mutually interacting drug mixtures

Parvinder Singh, Saurabh J. Desai, Anthony P. Simonelli, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

1967

Language:

english

File:

PDF, 602 KB

english, 1967

10

Influence of benzalkonium chloride on the dissolution rate behavior of several solid-phase preparations of cholesterol in bile acid solutions

Kenneth M. Feld, William I. Higuchi, Ching-Chiang Su

Journal:

Journal of Pharmaceutical Sciences

Year:

1982

Language:

english

File:

PDF, 717 KB

english, 1982

11

Edward G. Feldmann, pharmaceutical chemist, pharmaceutical scientist, and editor of the Journal of Pharmaceutical Sciences

William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

1994

Language:

english

File:

PDF, 219 KB

english, 1994

12

Pore induction in human epidermal membrane during low to moderate voltage iontophoresis: A study using AC iontophoresis

S. Kevin Li, Abdel-Halim Ghanem, Kendall D. Peck, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 190 KB

english, 1999

13

Morphologic and microbiologic features of Pseudomonas aeruginosa pneumonia in normal hamsters

Jacqueline J. Coalson, Junji H. Higuchi, Mary L. Williams, Waldemar G. Johanson Jr.

Journal:

Experimental and Molecular Pathology

Year:

1986

Language:

english

File:

PDF, 6.82 MB

english, 1986

14

Principles and criteria in the development and optimization of topical therapeutic products: Sponsored by the American Association of Pharmaceutical Scientists (AAPS) and U.S. Food and Drug Administration (FDA)

Vinod P. Shah, Charan R. Behl, Gordon L. Flynn, William I. Higuchi, Hans Schaefer, Brian W. Barry, Charan R. Behl, Dale P. Conners, C.Carnot Evans, Gordon L. Flynn, Thomas J. Franz, Eugene H. Gans, Wi

Journal:

International Journal of Pharmaceutics

Year:

1992

Language:

english

File:

PDF, 793 KB

english, 1992

15

Investigation of properties of human epidermal membrane under constant conductance alternating current iontophoresis

Honggang Zhu, Kendall D Peck, David J Miller, Mark R Liddell, Guang Yan, William I Higuchi, S.Kevin Li

Journal:

Journal of Controlled Release

Year:

2003

Language:

english

File:

PDF, 684 KB

english, 2003

16

160-Gb/s Optical Packet Switching Subsystem With a Monolithic Optical Phased-Array Switch

Soganci, I.M., Calabretta, N., Tanemura, T., Wenrui Wang, Raz, O., Higuchi, K., Williams, K.A., de Vries, T., Dorren, H.J.S., Nakano, Y.

Journal:

IEEE Photonics Technology Letters

Year:

2010

Language:

english

File:

PDF, 374 KB

english, 2010

17

Capric Acid Absorption in the Presence of Hydroxypropyl-β-Cyclodextrin in the Rat Ileum using the In Situ Single-Pass Perfusion Technique

Hymas, Richard V., Ho, Norman F. H., Higuchi, William I.

Journal:

Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 942 KB

english, 2014

18

An Application of Transdermal Antiviral Delivery Systems to the Establishment of a Novel Animal Model Approach in the Efficacy Evaluation for Dermatological Formulations

Su, Muh-Hwan, Lee, Paul H., Ghanem, Abdel-Halim, Kern, Earl R., Higuchi, William I.

Journal:

Drug Development and Industrial Pharmacy

Year:

1994

Language:

english

File:

PDF, 1.55 MB

english, 1994

19

Editorial

William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2000

Language:

english

File:

PDF, 82 KB

english, 2000

20

Kinetics and Mechanisms of Cholesterol Gallstone Dissolution

William I. Higuchi

Journal:

Year:

1984

Language:

english

File:

PDF, 454 KB

english, 1984

21

Effect of particle size of metastable calcium phosphates on mechanical strength of a novel self-setting bioactive calcium phosphate cement

Makoto Otsuka, Yoshihisa Matsuda, Yoshiko Suwa, Jeffrey L. Fox, William I. Higuchi

Journal:

Journal of Biomedical Materials Research Part B: Applied Biomaterials

Year:

1995

Language:

english

File:

PDF, 561 KB

english, 1995

22

Effect of controlled zinc release on bone mineral density from injectable Zn-containing β-tricalcium phosphate suspension in zinc-deficient diseased rats

Makoto Otsuka, Yuko Ohshita, Sunao Marunaka, Yoshihia Matsuda, Atsuo Ito, Noboru Ichinose, Kuniko Otsuka, William I. Higuchi

Journal:

Journal of Biomedical Materials Research Part A

Year:

2004

Language:

english

File:

PDF, 316 KB

english, 2004

23

Effect of nanostructure on biodegradation behaviors of self-setting apatite/collagen composite cements containing vitamin K2 in rats

Makoto Otsuka, Tomoaki Kuninaga, Kuniko Otsuka, William I. Higuchi

Journal:

Journal of Biomedical Materials Research Part B: Applied Biomaterials

Year:

2006

Language:

english

File:

PDF, 540 KB

english, 2006

24

Induction of granuloma-dependent angiotensin-converting enzyme and eosinophil chemotactic factor in the skin of athymic nude mice

Kazunori Kanazawa, Mitsunari Higuchi, Mitsuse Okamoto, Kimie Fukuyama, William L. Epstein

Journal:

Journal of Cellular Biochemistry

Year:

1987

Language:

english

File:

PDF, 560 KB

english, 1987

25

Mechanistic study of alkyl azacycloheptanones as skin permeation enhancers by permeation and partition experiments with hairless mouse skin

Ning He, S. Kevin Li, T. Marjukka Suhonen, Kevin S. Warner, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 171 KB

english, 2003

26

A Systematic examination of the in vitro Ussing chamber and the in situ single-pass perfusion model systems in rat ileum permeation of model solutes

Keiko Tsutsumi, S. Kevin Li, Abdel-Halim Ghanem, Norman F.H. Ho, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 217 KB

english, 2003

27

Structure–activity relationship for chemical skin permeation enhancers: Probing the chemical microenvironment of the site of action

Kevin S. Warner, S. Kevin Li, Ning He, T. Marjukka Suhonen, Doungdaw Chantasart, Durgadas Bolikal, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 203 KB

english, 2003

28

Iontophoretic transport of oligonucleotides across human epidermal membrane: A study of the Nernst–Planck model

S. Kevin Li, Abdel-Halim Ghanem, Ching-Leou Teng, Gregory E. Hardee, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2001

Language:

english

File:

PDF, 287 KB

english, 2001

29

Quantification of pore induction in human epidermal membrane during iontophoresis: The importance of background electrolyte selection

Honggang Zhu, Kendall D. Peck, S. Kevin Li, Abdel-Halim Ghanem, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2001

Language:

english

File:

PDF, 191 KB

english, 2001

30

Mechanistic studies of branched-chain alkanols as skin permeation enhancers

Doungdaw Chantasart, S. Kevin Li, Ning He, Kevin S. Warner, Sompol Prakongpan, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 266 KB

english, 2004

31

Influences of alkyl group chain length and polar head group on chemical skin permeation enhancement

Kevin S. Warner, S. Kevin Li, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2001

Language:

english

File:

PDF, 174 KB

english, 2001

32

Mechanistic study of chemical skin permeation enhancers with different polar and lipophilic functional groups

Ning He, Kevin S. Warner, Doungdaw Chantasart, Dalia S. Shaker, William I. Higuchi, S. Kevin Li

Journal:

Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 234 KB

english, 2004

33

Quantitative study of electrophoretic and electroosmotic enhancement during alternating current iontophoresis across synthetic membranes

Guang Yan, S. Kevin Li, Kendall D. Peck, Honggang Zhu, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 302 KB

english, 2004

34

Effects of electrophoresis and electroosmosis during alternating current iontophoresis across human epidermal membrane

Guang Yan, Kendall D. Peck, Honggang Zhu, William I. Higuchi, S. Kevin Li

Journal:

Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 170 KB

english, 2005

35

Influence of asymmetric donor–receiver ion concentration upon transscleral iontophoretic transport

S. Kevin Li, Yanhui Zhang, Honggang Zhu, William I. Higuchi, Henry S. White

Journal:

Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 204 KB

english, 2005

36

Comparison of the effects of chemical permeation enhancers on the lipoidal pathways of human epidermal membrane and hairless mouse skin and the mechanism of enhancer action

Doungdaw Chantasart, Piyanuch Sa-Nguandeekul, Sompol Prakongpan, S. Kevin Li, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 262 KB

english, 2007

37

Examination of barriers and barrier alteration in transscleral iontophoresis

Sarah A. Molokhia, Eun-Kee Jeong, William I. Higuchi, S. Kevin Li

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 518 KB

english, 2008

38

Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions

William I. Higuchi, Chinn-Shin Tzeng, Shyh-Jye Chang, Huey-Jenn Chiang, Chen-Lun Liu

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 193 KB

english, 2008

39

Silicone elastomer uptake method for determination of free 1-alkyl-2-pyrrolidone concentration in micelle and hydroxypropyl-β-cyclodextrin systems used in skin transport studies

Kevin S. Warner, Dalia S. Shaker, Sarah Molokhia, Qingfang Xu, Jinsong Hao, William I. Higuchi, S. Kevin Li

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 231 KB

english, 2008

40

Systematic studies on the paracellular permeation of model permeants and oligonucleotides in the rat small intestine with chenodeoxycholate as enhancer

Keiko Tsutsumi, S. Kevin Li, Richard V. Hymas, Ching-Leou Teng, Lloyd G. Tillman, Gregory E. Hardee, William I. Higuchi, Norman F.H. Ho

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 330 KB

english, 2008

41

Efficacy of the injectable calcium phosphate ceramics suspensions containing magnesium, zinc and fluoride on the bone mineral deficiency in ovariectomized rats

Makoto Otsuka, Ayako Oshinbe, Racquel Z. LeGeros, Yoshihiro Tokudome, Atsuo Ito, Kuniko Otsuka, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 461 KB

english, 2008

42

Iontophoretic transport across a multiple membrane system

Sarah A. Molokhia, Yanhui Zhang, William I. Higuchi, S. Kevin Li

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 291 KB

english, 2008

43

A liposome permeability model for stratum corneum lipid bilayers based on commercial lipids

Marjukka Suhonen, S. Kevin Li, William I. Higuchi, James N. Herron

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 405 KB

english, 2008

44

Effect of geometrical structure on drug release rate of a three-dimensionally perforated porous apatite/collagen composite cement

Makoto Otsuka, Hidenori Nakagawa, Atsuo Ito, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 292 KB

english, 2010

45

Transport behavior of hairless mouse skin during constant current DC iontophoresis i: Baseline studies

Mark R. Liddell, S. Kevin Li, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 259 KB

english, 2011

46

Editorials

Edward G. Feldmann, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 296 KB

english, 2011

47

Transport behavior of hairless mouse skin during constant current DC iontophoresis, part 2: Iontophoresis of nonionic molecules with cotransport of polystyrene sulfonate oligomers

Mark R. Liddell, S. Kevin Li, William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 259 KB

english, 2011

48

Rate of solute transport out of emulsion droplets in micron size range

William I. Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

1964

Language:

english

File:

PDF, 323 KB

english, 1964

49

Stress-relaxation studies on hydrated callus strips II. Effects of some electrolytes and nonelectrolytes in aqueous solutions

William J. Tillman, Takeru Higuchi

Journal:

Journal of Pharmaceutical Sciences

Year:

1964

Language:

english

File:

PDF, 481 KB

english, 1964

50

Cholesterol particle growth and dissolution rates in aqueous media

William I. Higuchi, Hosny Y. Saad

Journal:

Journal of Pharmaceutical Sciences

Year:

1965

Language:

english

File:

PDF, 441 KB

english, 1965